Open AccessThe pattern of systemic inflammation index in normotensive non-dipper and dipper hypertensive patients
Author(s) -
Nadir Emlek,
Cihan Aydın
Publication year - 2021
Publication title -
heart, vessels and transplantation
Language(s) - English
Resource type - Journals
eISSN - 1694-7894
pISSN - 1694-7886
DOI - 10.24969/hvt.2021.291
Subject(s) - dipper , medicine , systemic inflammation , inflammation , ambulatory blood pressure , blood pressure , mean platelet volume , gastroenterology , essential hypertension , lymphocyte , pulse pressure , neutrophil to lymphocyte ratio , cardiology , platelet
Objective: Continuous inflammation at the level of the vascular endothelium plays an important role in the formation of hypertension. Diurnal blood pressure (BP) variation also is a risk factor for hypertensive target organ damage. This study planned to evaluate these inflammation processes in normotensive and hypertensive patients.Methods: This study is observational cross-sectional cohort in-design. 151 patients with a prediagnosis of hypertension included. The patients were divided into three groups (group 1: dipper normotensive, group 2: non-dipper normotensive, group 3: dipper-hypertensive) based on the results of ambulatory blood pressure monitoring. The groups were compared in terms of systemic inflammation index (SII; platelet count×neutrophil count/lymphocyte count), neutrophil to lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and other inflammation processes.Results: There was a significant difference between the three groups in terms of mean platelet volume (MPV) and red blood cell distribution width (RDW) levels (p=0.001 and p<0.001, respectively). A statistically significant difference was found between the groups in terms of NLR, PLR, systemic inflammation index, lymphocyte-monocyte ratio (LMR). In subgroup analysis, NLR and systemic inflammation index were similar in group 2 and group 3, but higher than in group 1 in both groups. LMR was similar in group 2 and group 3 but lower than in group 1. In subgroup analysis PLR levels were similar in group 2 and group 3 but higher than group 1 in both groups.Conclusion: This study showed that normotensive non-dipper patients had inflammation as much as dipper hypertensive patients according to measurement of MPV, RDW systemic inflammation index, PLR, NLR levels.