Open AccessMicrogravity Significantly Influences Neural Stem Cells Size and Numbers: Implications for Long-term Space Missions
Author(s) -
Sophia Shaka,
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Nicolas Carpo,
V.H. Tran,
Carlos Cepeda,
Araceli EspinosaJeffrey,
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Publication year - 2021
Publication title -
hsoa journal of stem cells research, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 2381-2060
DOI - 10.24966/srdt-2060/100088
Subject(s) - neural stem cell , somatic cell , term (time) , stem cell , space (punctuation) , microbiology and biotechnology , biology , biological system , physics , chemistry , neuroscience , computer science , biochemistry , quantum mechanics , gene , operating system
There are two approaches used to study the effects of microgravity on cells -- using simulated microgravity on Earth (sim-µG) or sending cells to space (SPC-µG). We have recently reported that human neural stem cells (NSCs) proliferated seven-times more while in space than Ground Control (GC) NSCs on Earth. Here, using time-lapse microscopy, we determined that in both sim-µG and SPC-µG there are two cell subpopulations distinguished by differences in somatic diameter