Open AccessMechanical and Thermodynamic Properties of Mesenchymal Stem Cells Differentiated into Myofibroblasts: A Commentary on the Article “Statistical Mechanics of Non-Muscle Myosin IIA in Human Bone Marrow-Derived Mesenchymal Stromal Cells Seeded in a Collagen Scaffold: A Thermodynamic Near-Equilibrium Linear System Modified by the Tripeptide Arg-Gly-Asp (RGD)”
Author(s) -
Yves Lecarpentier
Publication year - 2021
Publication title -
hsoa journal of stem cells research, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 2381-2060
DOI - 10.24966/srdt-2060/100075
Subject(s) - mesenchymal stem cell , myofibroblast , stromal cell , myosin , microbiology and biotechnology , bone marrow , stem cell transplantation for articular cartilage repair , fibrosis , pathology , chemistry , cancer research , biology , cellular differentiation , medicine , adult stem cell , biochemistry , gene
Mesenchymal Stem Cells (MSCs) are multipotent stromal cells found in bone marrow and have the capacity to differentiate into myofibroblast. In contractile myofibroblasts, the molecular motor is the non-muscle myosin (NMIIA) which differs from the muscle myosin by its ultra-slow kinetics. The differentiation of MSCs into myofibroblasts is promoted by the “Transforming Growth Factor” (TGF-b) which represents a potentially target against tissue fibrosis and cancer.