Open AccessArtificial Nerve Conduits with Stem Cell Transplantation used for Bridging a Long Nerve Gap: A Review of Experimental Studies in Rats
Author(s) -
Ryosuke Kakinoki
Publication year - 2021
Publication title -
hsoa journal of stem cells research, development and therapy
Language(s) - English
Resource type - Journals
ISSN - 2381-2060
DOI - 10.24966/srdt-2060/100068
Subject(s) - decellularization , vascularity , peripheral nerve , nerve guidance conduit , medicine , mesenchymal stem cell , epineurial repair , sural nerve , stem cell , transplantation , bridging (networking) , regeneration (biology) , anatomy , biomedical engineering , tissue engineering , pathology , surgery , biology , microbiology and biotechnology , computer network , computer science
Cells, scaffolds, growth factors and vascularity are four pillars in regenerative medicine. In the field of peripheral nerve regeneration, studies have been performed based on these four pillars. We have created an artificial nerve conduit model in rats, which can be applied to clinical settings in near future. Our artificial conduit is made of a polyglycolic acid filament-meshed tube containing a sural vascular pedicle and decellularized allogenic nerve basal lamellae implanted by bone marrow derived mesenchymal stem cells.