Potentiation of ATRA Activity in HL-60 Cells by Targeting Methylation Enzymes | Zendy

Ming C. Liau | Zendy

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Potentiation of ATRA Activity in HL-60 Cells by Targeting Methylation Enzymes

Author(s) -

Ming C. Liau

Publication year - 2019

Publication title -

cytokines their relation with mineral dust induced diseases

Language(s) - English

Resource type - Journals

ISSN - 2639-5649

DOI - 10.24966/ppp-5649/100009

Subject(s) - retinoic acid , acute promyelocytic leukemia , cancer research , retinoic acid receptor , chemistry , histone deacetylase , leukemia , methyltransferase , promyelocytic leukemia protein , tretinoin , histone , methylation , biochemistry , biology , dna , immunology , gene

All Trans Retinoic Acid (ATRA) is a Differentiation Inducer (DI) of Acute Promyelocytic Leukemia (APL) with proven clinical utility. Its benefits for other types of Acute Myelocytic Leukemia (AML) have been limited. In APL, ATRA targets the PML-RARA (promyelocytic leukemia/retinoic acid receptor-alpha)/DNA methyltransferase (DNMT)/Histone Deacetylase (HDAC) complex, facilitating its

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