Open AccessQuercetin Prophylaxis: A Novel Approach To Prevent Hypoxia-Mediated Increase In Oxidative Stress, Pde-5 Activity And Transvascular Leakage In The Lungs Of Rats
Author(s) -
Sagi SSK
Publication year - 2020
Publication title -
hsoa journal of pulmonary medicine and respiratory research
Language(s) - English
Resource type - Journals
ISSN - 2573-0177
DOI - 10.24966/pmrr-0177/100041
Subject(s) - hypoxia (environmental) , hypoxic pulmonary vasoconstriction , oxidative stress , lung , vasoconstriction , medicine , pharmacology , chemistry , oxygen , organic chemistry
An increase in the vascular permeability of alveolar epithelium has found to be the major manifestation of hypoxia exposure. This study examined the efficacy of quercetin in preventing the hypoxia-mediated increase in Phosphodiesterase-5 (PDE-5) levels in the lung, leading to the diminution of alveolar smooth muscles vasoconstriction and curtailed transvascular leakage. Quercetin is noted to be a direct antagonist of PDE-5 in the lungs of rats under hypoxia, which by abrogating oxidative stress, prevents fluid accumulation in the lungs as a consequence of HAPE.