Open AccessProtective Effect of 17β Estradiol against Kidney Injury in a Mouse Model of Unilateral Renal Ischemia
Author(s) -
Carolyn M. Ecelbarger
Publication year - 2021
Publication title -
hsoa journal of nephrology and renal therapy
Language(s) - English
Resource type - Journals
ISSN - 2473-7313
DOI - 10.24966/nrt-7313/100046
Subject(s) - medicine , kidney , ischemia , atrophy , renal ischemia , renal injury , fibrosis , endocrinology , urology , pathology , reperfusion injury
Renal ischemia can lead to irreversible damage to the kidney including atrophy and fibrosis. Young females generally experience attenuated pathology due to the protective actions of ovarian steroids, in particular 17β-Estradiol (E2); however, the mechanisms of action remain murky.