Open AccessCelecoxib Decreases Gcf Prostaglandin E2 Levels in Chronic Periodontitis Patients
Author(s) -
Athena Papas
Publication year - 2020
Publication title -
hsoa journal of dentistry
Language(s) - English
Resource type - Journals
ISSN - 2473-6783
DOI - 10.24966/dohc-6783/100012
Subject(s) - celecoxib , prostaglandin e2 , scaling and root planing , chronic periodontitis , periodontology , medicine , periodontitis , dentistry , prostaglandin , mediator
Prostaglandin E2 (PGE2) is a key mediator associated with periodontal bone loss. We recently demonstrated (Yen, et al, J Periodontology 79:104, 2008) that adjunctive use of Celecoxib (a COX-2 selective inhibitor) in conjunction with Scaling and Root Planning (SRP) resulted in significant reduction in Pocket Depth (PD) and gain in Clinical Attachment (CAL) in Chronic Periodontitis (CP) patients.