Open AccessExpression Of MiRNA-33 And MiRNA-155 In Symptomatic And Asymptomatic Carotid Artery Stenosis
Author(s) -
Noemi Cifani,
Ospedale Sant’Andrea
Publication year - 2020
Publication title -
hsoa journal of angiology and vascular surgery
Language(s) - English
Resource type - Journals
ISSN - 2572-7397
DOI - 10.24966/avs-7397/100047
Subject(s) - asymptomatic , medicine , stenosis , peripheral blood mononuclear cell , microrna , carotid arteries , cardiology , peripheral , peripheral blood , pathology , gene , biology , biochemistry , in vitro
Background: The aim of this study was to evaluate miRNA-33 and miRNA-155 expression in Peripheral Blood Mononuclear Cells (PBMC) and carotid specimens of patients affected by Critical Carotid Artery Stenosis (CAS). Material and Methods: We selected 17 asymptomatic (CAS-A group) and 10 symptomatic (CAS-S group) patients with CAS. Ten patients with traditional cardiovascular risk factors (RF group), matched for age and sex, were used as control group. Results: A significant increase in miRNA-33 expression was observed both in peripheral blood and in carotid specimens of CAS-A patients (p 0.04) in comparison with CAS-S and RF, whereas no significant difference were found among the groups regarding miRNA-155 expression both in peripheral blood and in carotid specimens. Conclusions: This is to our knowledge the first report on miRNAs expression in human PBMCs from CAS patients. Results of this study suggest that miRNA-33 in involved in the process underling plaque formation and growth, but not in plaque instability and ischemic brain damage, whereas miRNA-155 is expressed during all the phases of atherosclerotic disease.