Open AccessRefractory Hypotension Related to Systemic Mastocytosis Diagnosed After Cytoreductive Therapy for Acute Myeloid Leukemia
Author(s) -
Denisa Ferastraoaru
Publication year - 2017
Publication title -
hsoa journal of allergy disorders and therapy
Language(s) - English
Resource type - Journals
ISSN - 2470-749X
DOI - 10.24966/adt-749x/100006
Subject(s) - systemic mastocytosis , medicine , myeloid leukemia , refractory (planetary science) , bone marrow , systemic therapy , biopsy , chromosomal translocation , leukemia , myeloid , oncology , dermatology , gene , cancer , biology , astrobiology , breast cancer , biochemistry
Systemic Mastocytosis (SM) can be associated with Acute Myeloid Leukemia (AML) and mast cells can be masked on bone marrow biopsy by the high burden of blast cells. Most of the SM-AML patients have associated translocation t(8;21) and mutation of D816V KIT gene which were not present in the reported case. None of the SM-AML cases described in the literature had systemic symptoms secondary to SM. This is the first reported case of life-threatening symptomatic SM in a patient with SM-AML. Checking