Open AccessThe synthesis of 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol and its interaction with aldehydes
Author(s) -
D. М. Zozulynets,
А. Г. Каплаушенко,
А. С. Коржова
Publication year - 2021
Publication title -
žurnal organìčnoï ta farmacevtičnoï hìmìï
Language(s) - English
Resource type - Journals
eISSN - 2518-1548
pISSN - 2308-8303
DOI - 10.24959/ophcj.21.188137
Subject(s) - chemistry , 1,2,4 triazole , thiol , quinoline , aryl , triazole , amino acid , reactivity (psychology) , 1,2,3 triazole , aldehyde , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis , biochemistry , medicine , alkyl , alternative medicine , pathology
Aim. To synthesize 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol and study its reactivity in the reactionwith aldehydes.Results and discussion. 4-Amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol was synthesized, and a number of 4-(ethyl, aryl)idenamino derivatives were obtained on its basis.Experimental part. Using a series of four successive reactions based on quinoline-2-carboxylic acid, 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol was synthesized; its interaction with aldehydes allowed to obtain a number of 4-(ethyl, aryl)idenamino derivatives. The structure of all compounds synthesized was confrmed by IR and 1H NMR spectroscopy, as well as by elemental analysis, and their purity by thin layer chromatography.Conclusions. 4-Amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol has been synthesized. It has been found that its interaction with aldehydes leads to the formation of new 4-((ethyl, aryl)idenamino)-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiols.Key words: 5-(quinolin-2-yl)-1,2,4-triazole-3-thiol; 4-arylidenamino derivatives; quinaldic acid; biologicalactivity