Open AccessAntimicrobial photodynamic therapy in voice rehabilitation of patients after laryngectomy
Author(s) -
С. А. Шинкарев,
С. В. Болдырев,
А П Загадаев,
В. Н. Подольский,
В. А. Борисов,
Ю. И. Костюшина
Publication year - 2021
Publication title -
biomedical photonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.303
H-Index - 7
ISSN - 2413-9432
DOI - 10.24931/2413-9432-2021-10-1-11-16
Subject(s) - photodynamic therapy , laryngectomy , voice prosthesis , medicine , antimicrobial , fluconazole , rehabilitation , photosensitizer , surgery , larynx , adverse effect , audiology , antifungal , dermatology , physical therapy , chemistry , organic chemistry
The article is devoted to the problem of voice rehabilitation of patients after laryngectomy. Modern possibilities of repairing laryngeal vocal function, methods for extending the lifetime of voice prostheses are considered. The author’s method of prevention of infection of vocal prostheses using the antimicrobial photodynamic therapy (PDT) with chlorin-type photosensitizer Radagel is presented. Performing antimicrobial PDT of vocal prostheses increased the average operating time to 11.9 months compared to the control group (6.8 months), where a monthly dose of 150 mg of fluconazole was used for prevention. The method developed by the authors makes it possible to significantly extend the lifetime of vocal prostheses, is devoid of adverse events, is well tolerated by patients.