Open AccessCOMPARATIVE STUDIES OF EFFICACY OF PHOTODYNAMIC THERAPY AND CRYOTHERAPY FOR TREATMENT OF ACTINIC KERATOSIS
Author(s) -
Т. Е. Сухова,
К. А. Чанглян,
А. В. Молочков,
В. А. Молочков,
С. В. Коренев,
Ж. С. Кунцевич,
Ю. В. Молочкова,
В. Н. Галкин,
Ю. С. Романко
Publication year - 2016
Publication title -
biomedical photonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.303
H-Index - 7
ISSN - 2413-9432
DOI - 10.24931/2413-9432-2016-5-3-19-29
Subject(s) - photodynamic therapy , cryotherapy , actinic keratosis , medicine , dermatology , photosensitizer , keratosis , surgery , pathology , chemistry , photochemistry , basal cell , organic chemistry
The results of a study on the eectiveness of photodynamic therapy with a photosensitizer fotoditazin and cryotherapy for actinic keratosis are represented in the article. The study included 80 patients with 215 lesions, among them erythematous form of actinic keratosis was diagnosed in 151 (70.2%) cases, hyperkeratotic form – in 46 (21.4%) cases, a pigmented form – in 12 (5.6%) and an atypical variant of the disease – in 6 (2.8%) cases. According to histological type the distribution of tumor was as follows: 19 (54.3%) cases were diagnosed as hypertrophic type, 6 (17.1%) – atrophic, 8 (22.9%) – bowenoid and 2 (5.7% ) – pigmented type. Patients from the study group received one session of photodynamic therapy using laser unit "LAMI" (662 nm) after 2 hours of application of fotoditazin 0.5% gel at dose of 0,2-0,3 ml per 1 cm2 of actinic keratosis focus with the following parameters: the energy density of the laser radiation – 200 J/cm2, power density – 0.14–0.48 W/cm2. In the control group patients underwent cryotherapy with liquid nitrogen with an exposure of 30-60 sec. The comparative analysis of the immediate results showed a tendency for the efficacy of photodynamic therapy to increase (the rate of complete regression was 92.5%) compared with cryotherapy (85.0%) (p>0,05). There were also a tendency for long-term results after photodynamic therapy to improve: three-year recurrence-free survival was 94.6% and 88.2%, respectively. For the photodynamic therapy there were signicantly fewer adverse reactions, the epithelization time in lesions was signicantly shorter. Compared with cryotherapy the photodynamic therapy provided signicantly better cosmetic results (p <0.01) and can be used for out-patient treatment of patients with actinic keratosis.