Open AccessMemelilerde Genomik Damgalanmanın Epigenetik Düzenleyicileri
Author(s) -
Zeynep Demirtaş,
Fatih Bilgi,
Levent Mercan
Publication year - 2016
Publication title -
türk tarım - gıda bilim ve teknoloji dergisi
Language(s) - English
Resource type - Journals
ISSN - 2148-127X
DOI - 10.24925/turjaf.v4i12.1139-1142.958
Subject(s) - genomic imprinting , imprinting (psychology) , epigenetics , biology , gene , genetics , allele , dna methylation , gene expression
Genomic imprinting is expression of gene’s only one allele in one of homolog chromosome depending on its maternal or paternal origin. A waste number of genes which are under the imprinting effect were identified as it has a key role in mammalian growth. The first three genes which is identified as imprinted are Igf2r, Igf2 and H19 which are first discovered in mouse genome. Over a hundred genes are identified as imprinted in mammals. Most of the imprinted genes are considered as they have a key role in growth and differentiation. In this review, epigenetic regulators of imprinted genes in mammals were mentioned.