Association between GSTT1 Homozygous Deletion and Risk of Pancreatic Cancer: A Meta Analysis | Zendy

Junpeng Cui | Zendy; Meiyi Lin | Zendy; Zhenghao Liu | Zendy; Baolin Liu | Zendy

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Association between <i>GSTT</i>1 Homozygous Deletion and Risk of Pancreatic Cancer: A Meta Analysis

Author(s) -

Junpeng Cui,

Meiyi Lin,

Zhenghao Liu,

Baolin Liu

Publication year - 2019

Publication title -

chinese medical sciences journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.215

H-Index - 21

ISSN - 1001-9294

DOI - 10.24920/003490

Subject(s) - medicine , pancreatic cancer , odds ratio , meta analysis , confidence interval , genotype , gastroenterology , publication bias , oncology , cancer , subgroup analysis , genetics , gene , biology

Objective To clarify the possible association of GSTT 1 homozygous deletion with the susceptibility to pancreatic cancer. Methods We searched PubMed database, Chinese Journal Full Text Database (CNKI), and EMBASE to find the eligible studies published up to April 18, 2018 for evaluating the relationship between GSTT 1 homozygous deletion and pancreatic cancer. The frequency of null genotype for GSTT 1 between the pancreatic cancer group and the healthy control group was compared with Chi - square est, and odds ratios ( OR s) value and 95% confidence interval (95% CI ) were calculated. Results A total of 9 studies met the inclusion criteria, and 5952 cases consisting of 2387 pancreatic cancer patients and 3565 healthy controls were included in the meta analysis. Compared with the control group, frequency of null genotype for GSTT 1 in the pancreatic cancer group was higher (33.4% vs . 38.7%, OR = 1.26, 95% CI = 1.01-1.58, P = 0.04). Conclusion GSTT 1 homozygous deletion individuals may have higher susceptibility to pancreatic cancer.

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