Open AccessDoes benzo[a]pyrene affect the heart embryonic development?
Author(s) -
Łukasz M. Kołodziejczyk,
Magdalena Puzik,
Agnieszka Greń,
Marta Batoryna,
Grzegorz Formicki,
Edyta Kapusta
Publication year - 2018
Publication title -
annales universitatis paedagogicae cracoviensis. studia naturae
Language(s) - English
Resource type - Journals
eISSN - 2545-0999
pISSN - 2543-8832
DOI - 10.24917/25438832.3supp.4
Subject(s) - in ovo , pyrene , embryo , benzo(a)pyrene , embryonic heart , glutathione , embryonic stem cell , chemistry , microbiology and biotechnology , embryogenesis , biology , toxicology , andrology , biochemistry , medicine , organic chemistry , gene , enzyme
Benzo[a]pyrene is a polycyclic aromatic hydrocarbon of well proved toxic effect on animal cells and tissues. We used chicken in ovo developmental model to verify its influence on selected parameters of the heart rhythm and on the antioxidative defense in the heart tissue. We determined that the dose of 1 mg/kg weight of eggs of benzo[a]pyrene strongly activates the glutathione-dependent antioxidative system, but it do not significantly affect the heart conducting system of the chicken embryo. We postulate that further study on the benzo[a]pyrene action during embryonic development of birds is recommended.