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Effect of corvitin on oxygen homeostasis and blood gas transmitters in ischemia-reperfusion of the lower limbs
Author(s) -
В. Н. Засимович,
В. В. Зинчук,
Н. Н. Иоскевич
Publication year - 2021
Publication title -
regionarnoe krovoobraŝenie i mikrocirkulâciâ
Language(s) - English
Resource type - Journals
eISSN - 2712-9756
pISSN - 1682-6655
DOI - 10.24884/1682-6655-2021-20-2-37-44
Subject(s) - medicine , forearm , revascularization , ischemia , cardiology , occlusion , venous blood , reperfusion injury , anesthesia , surgery , myocardial infarction
. Reperfusion-reoxygenation syndrome (RRS) after revascularization of the lower limbs in obliterating atherosclerosis of the arteries is accompanied by a violation of the oxygen transport function of the blood (OTFB) and the content of gas transmitters (GTs). Reperfusion injury affects not only the tissues of the lower limbs, but also of anatomically distant organs, which supposes that effective RRS correction is required. Aim. To study the effect of Corvitin on the OTFB parameters and the content of GT of nitrogen monoxide (NO) and hydrogen sulfide (H 2 S) in the venous blood of the forearm after revascularization of the lower limb in chronic atherosclerotic occlusion of the superficial femoral artery (SFA). Materials and methods. The study included 118 male patients. Revascularization of the lower limb was carried out by the method of loop endaterectomy from the SFA. Patients of group I (n=52) received traditional medication, 51 patients of group II additionally received Corvitin. In the blood from the vein of the elbow bend before the operation, on the 3 rd and 8 th days after it, the indices of OTFB and GTs were determined. Results. In group I, on the 3 rd day after surgery, pO 2 increased in relation to healthy individuals by 5.2–18.5%, while pCO 2 decreased by 4.8–6.7%, depending on the stage of initial ischemia. The concentrations of NO and H 2 S increased by 9.2–50.1% and 9.2–21.1%, respectively. The increase in the parameters of hyperoxemia, hypocapnemia and GT after the return of blood circulation decreases with the use of Corvitin (p˂0.05). By the end of the early postoperative period, the indicators of OTFB and GT not only return to their initial values, but also do not significantly differ from the group of healthy individuals (p˃0.05). Conclusion. The use of Corvitin effectively corrects violations of OTFB and GT during ischemia-reperfusion of the lower limbs, which prevents tissue reperfusion damage.

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