Open AccessMicrocirculatory dopplerography as a method to evaluate drugs endothelial protective properties in type 2 diabetic patients
Author(s) -
А. В. Симаненкова,
М.Н. Макарова,
Л. В. Васина,
М. И. Бутомо,
Е. В. Шляхто,
Т. Д. Власов
Publication year - 2018
Publication title -
regionarnoe krovoobraŝenie i mikrocirkulâciâ
Language(s) - English
Resource type - Journals
eISSN - 2712-9756
pISSN - 1682-6655
DOI - 10.24884/1682-6655-2018-17-3-120-128
Subject(s) - medicine , endothelial dysfunction , acetylcholine , vasodilation , cardiology , type 2 diabetes , endothelin 1 , endocrinology , diabetes mellitus , receptor
Objective - to identify the most accurate way of drugs endothelial protective properties evaluation. Material and methods. Blood endothelin-1 (E) and acetylcholine-induced endothelial dependent vasodilation (EDV) were measured for 9 months in type 2 diabetic patients receiving either metformin (MET) (group 1) or MET and liraglutide (LIR) (group 2). Results. E was normal in group 1 at baseline and decreased only with glycaemia decline, in group 2 it was primarily increased and declined independently on glycaemia dynamics. In both groups E normalized in 6 months. EDV was impaired primarily in groups 1 and 2 and normalized only in group 2 in 9 months. Conclusions. LIR improves endothelial function, independently on glycaemia. Dopplerography in more accurate in drugs endothelial protective effects evaluation than circulating markers.