Open AccessNeuroprotective activity of orexin system in ischemic stroke
Author(s) -
Irina Filchenko,
Ю. В. Свиряев,
Т. Д. Власов
Publication year - 2018
Publication title -
regionarnoe krovoobraŝenie i mikrocirkulâciâ
Language(s) - English
Resource type - Journals
eISSN - 2712-9756
pISSN - 1682-6655
DOI - 10.24884/1682-6655-2018-17-2-4-11
Subject(s) - neuroprotection , stroke (engine) , medicine , orexin , ischemic stroke , orexin a , neuroscience , pharmacology , ischemia , anesthesia , bioinformatics , psychology , neuropeptide , biology , receptor , mechanical engineering , engineering
The protective potential of orexin system is a field of interest in the search of the new methods to diminish brain damage in ischemic stroke. The cytoprotective potential of orexins in hypoxic damage is associated with their antioxidant, anti-inflammatory and anti-apoptotic properties and with their ability to activate proliferation and normalize metabolism. Even though today little is known about the role of orexins in memory and pain in ischemic stroke, the common features of the pathogenesis of these disruptions and the mechanisms of orexin-associated protection could suggest the opportunity to use of orexins for correction of these complications following ischemic stroke. Further studies of the orexin-associated neuroprotection could become the further step on the way to the new therapeutic approaches in ischemic stroke.