Open AccessEffect of curcumin in the acute phase of ischemia in chronic cerebral hypoperfusion in rats
Author(s) -
Н. С. Щербак,
M. A. Popovetskiy,
G. Yu. Yukina,
М. М. Галагудза
Publication year - 2018
Publication title -
regionarnoe krovoobraŝenie i mikrocirkulâciâ
Language(s) - English
Resource type - Journals
eISSN - 2712-9756
pISSN - 1682-6655
DOI - 10.24884/1682-6655-2018-17-1-69-73
Subject(s) - curcumin , neuroprotection , cerebral hypoperfusion , ischemia , medicine , pharmacology , perfusion , anesthesia
Curcumin presents antioxidant and anti-inflammatory properties and can be considered as a neuroprotector. Data on doses and duration of application of curcumin to achieve protective effects in various types of ischemic brain injury is controversial. The purpose was to study the neuroprotective properties of curcumin in the acute phase of ischemia in chronic cerebral hypoperfusion in rats. It is shown that a single application of curcumin (300 mg/kg, i.p.) is not has neuroprotective effect in the acute phase of ischemia in chronic hypoperfusion in Wistar rats. The results allow to conclude that the neuroprotective effect of a single application of curcumin.