Open AccessThe no-reflow phenomenon: mechanisms and therapeutic targets
Author(s) -
М. М. Галагудза,
Dmitry Sonin,
Е. И. Почкаева
Publication year - 2018
Publication title -
regionarnoe krovoobraŝenie i mikrocirkulâciâ
Language(s) - English
Resource type - Journals
eISSN - 2712-9756
pISSN - 1682-6655
DOI - 10.24884/1682-6655-2018-17-1-5-12
Subject(s) - no reflow phenomenon , medicine , cardiology , thrombus , myocardial infarction , perfusion , percutaneous coronary intervention , pathophysiology , embolization , artery , radiology
The phenomenon of «no-reflow» refers to a state of myocardial tissue hypoperfusion or absence of perfusion after eliminating the cause of the occlusion of the coronary artery. Two main pathogenetic mechanisms may contribute to the development of no-reflow phenomenon after primary percutaneous coronary intervention in patients with myocardial infarction: ischemic-reperfusion injury of the microcirculatory vessels and embolization of the distal arterial bed with fragments of thrombus and atherosclerotic plaque. In this review, we describe the pathophysiological mechanisms of no-reflow, risk factors for no-reflow phenomenon, the principles of diagnosis and therapeutic targets.