Open AccessAnalysis of the reactivity of the endothelium of microvessels of the skin in chronic heart failure
Author(s) -
О. С. Полунина,
Л. П. Воронина,
Е. А. Полунина,
И В Севостьянова
Publication year - 2017
Publication title -
regionarnoe krovoobraŝenie i mikrocirkulâciâ
Language(s) - English
Resource type - Journals
eISSN - 2712-9756
pISSN - 1682-6655
DOI - 10.24884/1682-6655-2017-16-4-50-55
Subject(s) - endothelium , heart failure , cardiology , medicine , ventricle , ejection fraction
and purpose. The leading role in the pathogenesis of chronic heart failure (CHF) belongs to disturbances in the vascular endothelium. The aim of this work is the identification and analysis of the responses of the microvascular endothelium in patients with CHF, depending on the ejection fraction. Methods. We have examined 280 patients with CHF. Analysis of the reactivity of the endothelium of microvessels was carried out using laser Doppler flowmetry. Results. We have identified 3 types of response of the microvascular endothelium, thus all responses were decrement. Patients with CHF with reduced ejection fraction of the left ventricle was the predominant hyporeactive-decrement type response of the vascular endothelium. Conclusions. Results indicate torpidity of microvascular endothelium and the unidirectionality of the processes state changes of the vascular endothelium with a reduction in myocardial contractile function.