Open AccessThe role of hypoxia-inducible factorin the syndrome of chronic lower limb ischemia and influence of diabetes mellitus on process of angiogenesis
Author(s) -
М Н Кудыкин,
В. В. Бесчастнов,
R. A. Deryabin,
Г Е Шейко,
L. M. Celousova,
An. Belova
Publication year - 2017
Publication title -
regionarnoe krovoobraŝenie i mikrocirkulâciâ
Language(s) - English
Resource type - Journals
eISSN - 2712-9756
pISSN - 1682-6655
DOI - 10.24884/1682-6655-2017-16-3-4-9
Subject(s) - angiogenesis , hypoxia (environmental) , diabetes mellitus , medicine , hypoxia inducible factors , ischemia , wound healing , transcription factor , endocrinology , cancer research , immunology , biology , gene , chemistry , biochemistry , organic chemistry , oxygen
In this review, we pay attention to the role of the hypoxia-inducible factor (HIF) in the development of response of the organism to hypoxia. Special attention is given to the regulation of the cell responses to hypoxia in chronic peripheral artery disease in patients with diabetes mellitus (DM). Cells can survive by activation of a transcription of genes, involved in angiogenesis, glucose metabolism and cell proliferation. Artificial rising of concentration and activity of HIF stimulates an angiogenesis and improves ulcers healing of the lower extremities. The data of the literature are provided on the possible methods of increasing HIF concentration in tissues, which could be a new way to stimulate wound healing in the patients with DM.