Open AccessThe role of vasoactive medicine in treatment and rehabilitation of women with chronic pelvic pain syndrome
Author(s) -
С Х Аль-Шукри,
Igor V. Kuzmin,
Natalya Olegovna Shabudina,
М Н Слесаревская,
Ю А Игнашов
Publication year - 2017
Publication title -
regionarnoe krovoobraŝenie i mikrocirkulâciâ
Language(s) - English
Resource type - Journals
eISSN - 2712-9756
pISSN - 1682-6655
DOI - 10.24884/1682-6655-2017-16-2-25-31
Subject(s) - medicine , vasoactive , microcirculation , pentoxifylline , visual analogue scale , urology , regimen , pelvic pain , anesthesia , surgery
Purpose of the study: to analyze thee influence of vasoactive drugs in combination treatment in women with chronic pelvic pain syndrome (CPPS). Methods. 177 women with CPPS were examined. The average age was from 18 to 84 years (32.6±9.3). The duration of the disease ranged from 6 months to 6 years (an average of 2.7±0.9 years). To study the microcirculation of the bladder, the original technique of intravesical high-frequency ultrasonic dopplerography was used. An assessment of the intensity of the pain syndrome and urination disorders was carried out using the PUF questionnaire, and an evaluation of the psychoemotional status using the depression scale of A.T. Back. Results. After the examination, all patients with CPPS (n=177) were divided into 2 groups. In the 1st group (n=88) patients got standard therapy in the form of instillations of the bladder and suppositories with nonsteroidal anti-inflammatory drug. In the 2nd group (n=89), the patients received therapy in combination with a vasoactive drug (pentoxifylline in a dose 200 mg per day), 10 days. Analysis of the results of intravesical dopplerography of the bladder revealed differences in the state of microcirculation in women with CPPS, depending on the treatment regimen. The parameters of the microcirculatory bed have significantly improved at the arterial and capillary levels in patients with CPPS who got combined therapy with vasoactive drugs. The conducted therapy led to a significant decrease in the severity of the symptoms, which was confirmed with the questionnaire «Scale of Pelvic Pain Symptoms, Mandatory, Frequent Urination» and evaluation of the psychoemotional state according to the depression scale of A.T. Back. Conclusion. Insufficient effectiveness of standard CPPS therapy is caused in particular by altered blood flow in the bladder in this category of patients. Therefore, it is advisable to include vasoactive drugs in combination therapy of CPPS in women.