The impact of vascularization of interangiosomic zone in extended fasciocutaneous flap on its survival quality without pharmacological remedies and in conditions of antihypoxic tissue therapy

A flap on the basis of the superficial inferior epigastric artery (SIEA) extended cranially was formed in 24 rats and replanted after 90-minute femoral artery clipping at the point of SIEA embranchment. Mexidol was injected intramuscularly 30 or 60 minutes before the operation with repeated injection in 2 hours after it (E1 or E2 groups). Control (C) - injections of physiological solution. Methods: ultrasound flowmetry, computer-assisted planimetry of digital images of outer and inner flaps surfaces, histomorphometry, immunohistochemistry. 12 days after surgery in E1 and E2 the per cent area of epidermal defects significantly smaller than in C. The vascular pattern in inter-angiosome zone provide evidence that in E2 the intussusceptive mechanism of angiogenesis was predominant, resulting in increased in comparison with placebo and E2 capillarity of skin vascular plexuses, better liability of skin appendages and hypodermal fat tissue.