Open AccessInfluence of electromagnetic waves at frequencies of 150,176...150,664 GHz on brain microcirculation under conditions of prolonged experimental ischemia
Author(s) -
А. Н. Иванов,
М. А. Сахань,
И. О. Бугаева
Publication year - 2016
Publication title -
regionarnoe krovoobraŝenie i mikrocirkulâciâ
Language(s) - English
Resource type - Journals
eISSN - 2712-9756
pISSN - 1682-6655
DOI - 10.24884/1682-6655-2016-15-3-64-69
Subject(s) - microcirculation , ischemia , electromagnetic radiation , physics , acoustics , medicine , cardiology , optics
and purpose. Chronic cerebrovascular insufficiency - an actual problem of modern medicine. The key pathogenetic link of this group of diseases is a long-term violation of perfusion in the microvasculature. Currently, it is shown that low-intensity electromagnetic radiation at frequencies of millimeter and submillimeter ranges had an influence on processes in the microcirculation. The aim of this study was to examine the impact on perfusion indices in the vessels of the brain microcirculation in conditions of chronic ischemia. Materials and methods. Experiments were conducted on 52 male rats, which were divided into 3 groups. The first group consisted of 27 rats, which model of chronic cerebral hypoperfusion were reproduced. The second group consisted of 15 rats with chronic cerebral hypoperfusion and daily 30-minute exposure to low-intensity electromagnetic radiation at frequencies 150.176...150.664 GHz. 10 sham-operated rats for the analysis microcirculation mechanisms used the method of laser Doppler flowmetry were included in the third (control) group. The average perfusion, as well as active and passive mechanisms flow modulation were investigated. The main results and discussion. It was found that low-intensity electromagnetic radiation at frequencies 150.176...150.664 GHz contributes to the normalization of perfusion parameters in conditions of prolonged ischemia due to stimulation of active and passive flow modulation mechanisms. This effect is probably related to the prevention of endothelial dysfunction, as well as the influence of electromagnetic radiation on the functional activity of platelets and blood rheology. Conclusion. Thus, the results of the study suggest that low-intensity electromagnetic radiation at frequencies 150.176...150.664 GHz, is a promising method for non-drug correction of perfusion disturbances at long cerebrovascular insufficiency.