Open AccessThe role of thrombin in the development of complications after intracoronary stenting
Author(s) -
G. A. Berezovskaya,
М. А. Карпенко,
Petrishchëv Nn,
Alexey N. Yakovlev
Publication year - 2015
Publication title -
regionarnoe krovoobraŝenie i mikrocirkulâciâ
Language(s) - English
Resource type - Journals
eISSN - 2712-9756
pISSN - 1682-6655
DOI - 10.24884/1682-6655-2015-14-3-4-13
Subject(s) - restenosis , antithrombotic , thrombin , medicine , angioplasty , percutaneous coronary intervention , discovery and development of direct thrombin inhibitors , cardiology , stent , myocardial infarction , platelet
The purpose of this review is to increase the awareness of the experts about the multifaceted role of thrombin in the development of complications after percutaneous coronary intervention: restenosis and stent thrombosis. Here we present the analysis of clinical data obtained from 1990 to 2014, dealing with the study of basic mechanisms of thrombin action after angioplasty and coronary stenting, as well as the characteristics of the laboratory evaluation of thrombin generation and new antithrombotic drugs that block its activity. The article presents not only the original data, but also the personal view of the authors on the problem. The above information can be used in the learning process, as well as for the formation of new research directions and practical recommendations for physicians.