Open AccessFunctional characteristics of bone marrow stromal cells in patients with acute leukemia
Author(s) -
I. Barhatov,
Nikolay Tsvetkov,
Alena I. Shakirova,
D. S. Romanyuk,
O.G. Smykova,
L. S. Zubarovskaya,
Boris Afanasyev
Publication year - 2015
Publication title -
učënye zapiski sankt-peterburgskogo gosudarstvennogo medicinskogo universiteta im. akad. i.p. pavlova/učënye zapiski sankt-peterburgskogo gosudarstvennogo medicinskogo universiteta imeni akademika i. p. pavlova
Language(s) - English
Resource type - Journals
eISSN - 2541-8807
pISSN - 1607-4181
DOI - 10.24884/1607-4181-2015-22-4-48-51
Subject(s) - stromal cell , homing (biology) , haematopoiesis , bone marrow , stem cell , leukemia , cancer research , pathogenesis , immunology , acute leukemia , medicine , biology , microbiology and biotechnology , ecology
Pathogenesis of acute leukemia is associated with the presence of genetic and functional aberrations in hematopoietic stem cells. However, as one of the possible factors contributing to the progression of disease could be regarded as the pull of the stromal cells of bone marrow. In this paper we evaluated the major functional characteristics of stromal cells: proliferative activity, hematopoiesis supportive and differentiation ability, as well as analysis of the expression of adhesion molecules. Stromal cells derived from acute leukemia patients in comparison with healthy donors are characterized by a high proliferative activity and a pronounced ability to osteogenic and adipogenic differentiation with prominent expression of hematopoietic stem cells homing mediating molecules.