Open AccessDistribution of genotypes and alleles of the aldosterone-synthase gene in patients with abdominal obesity
Author(s) -
Д. Л. Бровин,
Е. А. Баженова,
Р. Е. Попов,
O. Belyaeva,
А. В. Березина,
Tatiana Karonova,
N. A. Korelskaya,
Татьяна Георгиевна Иванова,
Sofya Pchelina,
Е. И. Баранова,
О. А. Беркович,
E. V. Schlyakhto
Publication year - 2015
Publication title -
učënye zapiski sankt-peterburgskogo gosudarstvennogo medicinskogo universiteta im. akad. i.p. pavlova/učënye zapiski sankt-peterburgskogo gosudarstvennogo medicinskogo universiteta imeni akademika i. p. pavlova
Language(s) - English
Resource type - Journals
eISSN - 2541-8807
pISSN - 1607-4181
DOI - 10.24884/1607-4181-2015-22-2-20-23
Subject(s) - allele , aldosterone synthase , genotype , gene , abdominal obesity , obesity , aldosterone , genetics , biology , medicine , endocrinology , metabolic syndrome , renin–angiotensin system , blood pressure
We observed 140 patients with abdominal obesity (AO) (IDF, 2005), the residents of St. Petersburg (44.6 ± 0.6 years). Metabolic syndrome (MS) (IDF, 2005) was diagnosed in 49.2% of patients with AO. The most frequent component of MS in patients with AO was arterial hypertension (AH). The distribution of genotypes and -alleles of the aldosterone-synthase gene in patients with AO and in the comparison group (56 subjects without AO, 41.0 ± 1.1 years) didn't differ (p> 0.05). Levels of both systolic and diastolic blood pressure (BP) were higher in carriers of -344T allele of aldosterone-synthase gene. Plasma renin activity, plasma aldosterone and glucose levels, anthropometric parameters, serum blood lipids and carbohydrate metabolism indices in obese patients with different genotypes of aldosterone-synthase gene didn't differ. -344T allele of aldosterone-synthase gene in patients with AO is associated with the increased risk of AH.