Open AccessModern conception about cellular and molecular mechanisms of angiogenesis
Author(s) -
К. А. Хмельницкая,
А. Я. Гудкова,
Е. В. Шляхто
Publication year - 2015
Publication title -
učënye zapiski sankt-peterburgskogo gosudarstvennogo medicinskogo universiteta im. akad. i.p. pavlova/učënye zapiski sankt-peterburgskogo gosudarstvennogo medicinskogo universiteta imeni akademika i. p. pavlova
Language(s) - English
Resource type - Journals
eISSN - 2541-8807
pISSN - 1607-4181
DOI - 10.24884/1607-4181-2015-22-1-6-13
Subject(s) - angiogenesis , neovascularization , progenitor cell , biology , microbiology and biotechnology , notch signaling pathway , microrna , population , bone marrow , signal transduction , cancer research , immunology , neuroscience , stem cell , medicine , genetics , gene , environmental health
The review contains modern scientific literary data, recently conducted studies, which devoted to studying of molecular, cellular and genetic mechanisms in processes of angiogenesis. The authors describe in detail angiogenesis stages, value of the main proangiogenic and antiangiogenic factors, apoptosis factors, which have different orientation in regulation of blood vessels development. Role of a special population of bone marrow-derived stem cells - endothelial progenitor cells (EPC) in the neovascularization is analyzed. Participation of VEGF-dependent, ANG/Tie-dependent and Notch-signaling pathways, posttranscription regulation of a genome with participation of microRNA in angiogenesis processes are discussed and reviewed.