Open AccessIgM nephropathy in children: clinical, immunological, pathomorphological features
Author(s) -
I. A. Kazyra,
А. В. Сукало
Publication year - 2019
Publication title -
nefrologiâ
Language(s) - English
Resource type - Journals
eISSN - 2541-9439
pISSN - 1561-6274
DOI - 10.24884/1561-6274-2019-23-5-71-76
Subject(s) - medicine , regimen , nephropathy , nephrology , disease , immunology , pediatrics , endocrinology , diabetes mellitus
BACKGROUND. Studies on the problem of IgM nephropathy in children in the world literature are few. Data on the disease in adults and children In Belarus have not previously been presented. THE AIM: to analyze the clinical, immunological, morphological characteristics, treatment regimen and prognostic factors of IgM nephropathy in children. PATIENTS AND METHODS. The study included 153 patients during the 6 years observed in the Republican Center for Pediatric Nephrology, among whom 21 were diagnosed with IgM nephropathy. RESULTS. Analysis of clinical, morphological features, the participation of markers of activation of T- and B-lymphocytes, pro-inflammatory and profibrotic molecules was performed. CONCLUSIONS. In most cases, IgM nephropathy is characterized by steroid dependence or resistance, or frequent relapses, which dictates the need to join cytostatic agent. In childhood is characterized by a benign course with no signs of progression.