Open AccessRISK FACTORS FOR CARDIOVASCULAR COMPLICATIONS IN CHILDREN WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE
Author(s) -
Svetlana Papizh,
В. В. Длин,
И. В. Леонтьева,
Konstantin Tutelman
Publication year - 2017
Publication title -
nefrologiâ
Language(s) - English
Resource type - Journals
eISSN - 2541-9439
pISSN - 1561-6274
DOI - 10.24884/1561-6274-2017-21-2-62-72
Subject(s) - medicine , percentile , cardiology , body surface area , left ventricular hypertrophy , blood pressure , eccentric , autosomal dominant polycystic kidney disease , kidney , mathematics , statistics , physics , quantum mechanics
THE AIM: to identify the frequency and risk factors of cardiovascular lesions in children with ADPKD. PATIENTS AND METHODS: 54 children (27M/27F) with ADPKD were examined. The median age was 12 (IQR: 8.0;15.0) years. Standard two-dimensional echocardiogram was performed. LV mass (LVM) was calculated, normalized to height2.7 and estimated by centile tables. Relative wall thickness (RWT) was calculated. Patterns of abnormal LV geometry were defined as follows: LV concentric remodelling by normal LVMI and RWT ≥0.42; eccentric LV hypertrophy (LVH) by increased LVMI and RWT 90 percentile were more frequently detected systolic hypertension in the daytime, diastolic hypertension at night compared with children with LVMI 90 percentile compared with children with LVMI <90 percentile: (p=0.04), RR=1.7 (95% CI:1.1-2.6) and (р=0.04), RR=1.8 (95% CI:1.1-3.07). CONCLUSION: Risk factor for hypertension in children with ADPKD is increased renal volume. Risk factors for the development of left ventricular hypertrophy are systolic hypertension in the daytime, diastolic hypertension at night, increased kidney volume, and decreased IIC by DMSA.