Open AccessRENAL FUNCTION IN ADOLESCENTS WITH OBESITY
Author(s) -
Э. К. Петросян,
Е. А. Костерева,
С. Ю. Новиков,
Isidro Moreno,
П.В. Шумилов
Publication year - 2017
Publication title -
nefrologiâ
Language(s) - English
Resource type - Journals
eISSN - 2541-9439
pISSN - 1561-6274
DOI - 10.24884/1561-6274-2017-21-2-48-55
Subject(s) - microalbuminuria , renal function , medicine , endocrinology , obesity , overweight , blood pressure , insulin resistance
THE AIM. Determining the effect of obesity on renal function in children. PATIENTS AND METHODS. The study included 35 adolescents (30 boys and 5 girls, mean age 14.6±2.2 years) with overweight and differing degrees of obesity. In addition to clinical examination determined the presence and severity of risk factors for kidney disease in obesity, especially insulin resistance, lipid metabolism with the definition of atherogenic index (AI). To assess kidney function determined microalbuminuria (MAU) and glomerular filtration rate. RESULTS . Renal function in adolescents with obesity which manifests with increasing the excretion of albumin and decreasing the glomerular filtration rate (GFR) caused by lipid metabolism disorders: increase of lowdensity lipoprotein (LDL) level and decrease of high-density lipoprotein (HDL) level, which reflected on the atherogenic atherogenic index. The correlation between the level of MAU and GFR and atherogenic index (r= 0,42;p 0,05). CONCLUSION . In adolescents with overweight and obesity renal function is inversely proportional correlated with severity of lipid metabolism disorder, intensity of which is not dependent on the degree of overweight.