Open AccessAngulación de colédoco por sonda en T
Author(s) -
Gerardo Hernández-Puga,
Kevin David Laguna Maldonado,
Raúl Gregg-García,
Giselle Barrera-Zárate,
Feliciano David López-Ortiz,
Deyamira Matuz-Mares
Publication year - 2021
Publication title -
revista medica del instituto mexicano del seguro social/revista médica del instituto mexicano del seguro social
Language(s) - Spanish
Resource type - Journals
eISSN - 2448-5667
pISSN - 0443-5117
DOI - 10.24875/rmimss.m20000091
Subject(s) - art , physics
The AMP-activated kinase (AMPK) is an important enzyme involved in the regulation of cell metabolism, whose activity is regulated by several mechanisms, mainly the increased concentration of AMP. This enzyme catalyze the phosphorylation of several regulatory proteins implicated in the metabolism of lipids and carbohydrates, upregulating their catabolism. Thus, the AMPK plays an important role in the pathophysiology of some diseases, such as metabolic syndrome and type 2 diabetes mellitus, which have a high prevalence among Mexican population. Because of this, the AMPK has become a relevant target for several drugs used in the management of these pathologies, e.g. metformin and pioglitazone.