ASSOCIATION OF BDNF / TRKB AND NGF / TRKA LEVELS IN POSTMORTEM BRAIN WITH MAJOR DEPRESSION AND SUICIDE | Zendy

Lale Gönenir Erbay | Zendy; Rıfat Karlıdağ | Zendy; Mücahit Oruç | Zendy; Yılmaz Çiğremiş | Zendy; Osman Çelbiş | Zendy

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ASSOCIATION OF BDNF / TRKB AND NGF / TRKA LEVELS IN POSTMORTEM BRAIN WITH MAJOR DEPRESSION AND SUICIDE

Author(s) -

Lale Gönenir Erbay,

Rıfat Karlıdağ,

Mücahit Oruç,

Yılmaz Çiğremiş,

Osman Çelbiş

Publication year - 2021

Publication title -

psychiatria danubina

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.394

H-Index - 34

eISSN - 1849-0867

pISSN - 0353-5053

DOI - 10.24869/psyd.2021.491

Subject(s) - tropomyosin receptor kinase b , tropomyosin receptor kinase a , nerve growth factor , depression (economics) , neurotrophin , hippocampus , brain derived neurotrophic factor , neurotrophic factors , medicine , psychology , neurochemical , endocrinology , psychiatry , neuroscience , oncology , receptor , economics , macroeconomics

Suicide Attempts are the main complications of Major Depressive Episodes and are difficult to predict. There is still a lack of knowledge about its neurochemical aspects. There is increasing evidence that Brain-derived neurotrophic factor (BDNF) and Nerve growth factor (NGF) play a role in the pathophysiology and treatment of depression by binding and activating cognate receptors Tyrosine Kinase B (TrkB) and Tyrosie Kinase A (TrkA), respectively. This study was conducted to examine whether BDNF and / or TrkB as well as NGF and / or TrkA expression profiles were changed in the hippocampus of postmortem brain of individuals with depression who committed suicide.

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