Open AccessPERIPHERAL 8-ISO-PGF2Α AS A BIOMARKER IN BOSNIAN PATIENTS WITH ALZHEIMER’S DISEASE AND VASCULAR DEMENTIA
Author(s) -
Orhan Lepara,
Asija Začiragić,
Almir Fajkić,
Alma Džubur Kulenović,
Amela Dervišević,
Amina Valjevac,
Emina Kiseljaković,
Saida Ibragić
Publication year - 2020
Publication title -
psychiatria danubina
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.394
H-Index - 34
eISSN - 1849-0867
pISSN - 0353-5053
DOI - 10.24869/psyd.2020.389
Subject(s) - dementia , vascular dementia , peripheral , bosnian , biomarker , disease , medicine , alzheimer's disease , vascular disease , biology , biochemistry , linguistics , philosophy
Cerebrospinal levels of isoprostanes (IsoPs) have been established as biomarkers of oxidative stress in Alzheimer's disease (AD) and vascular dementia (VD). The value of peripheral levels in the diagnostics of these diseases is less conclusive. The aim of this study was to determine serum 8-iso-prostaglandin-F2alpha (8-iso-PGF2α) levels in Bosnian AD and VD patients and to establish whether there is an association between 8-iso-PGF2α serum concentration and cognitive impairment (CI) in patients with dementia.