Open AccessEXPRESSION OF SIR1-SIR7 GENES IN THE COURSE OF RECURRENT DEPRESSIVE DISORDERS
Author(s) -
Edyta Staroń,
Maria Filip,
Monika Talarowska,
Janusz Szemraj,
Piotr Gałecki
Publication year - 2019
Publication title -
psychiatria danubina
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.394
H-Index - 34
eISSN - 1849-0867
pISSN - 0353-5053
DOI - 10.24869/psyd.2019.347
Subject(s) - gene silencing , depression (economics) , gene , gene expression , messenger rna , statistical significance , biology , medicine , psychology , oncology , genetics , economics , macroeconomics
The role of sirtuins as a pathogenetic element of some mental disorders is becoming increasingly more common. They participate in many cellular processes, such as ageing, transcription, apoptosis, inflammatory processes, post-translational modification of proteins, gene transcription silencing, activation of DNA repair mechanisms, and regulation of many metabolic processes. The aim of this paper is to verify the statistical hypothesis assuming the difference in expression at the level of mRNA in genes for sirtuins 1-7 between patients with recurrent depressive disorders (rDD) and patients from the control group, and the hypothesis assuming the relation between the expression at the level of mRNA for these genes and clinical variables in the course of recurrent depressive disorders.