Open AccessROLE OF THE ALLELIC VARIATION IN THE 5-HYDROXYTRYPTAMINE RECEPTOR 1A (HTR1A) AND THE TRYPTOPHAN HYDROXYLASE 2 (TPH2) GENES IN THE DEVELOPMENT OF PTSD
Author(s) -
Afërdita Goçi Uka,
Ferid Agani,
Afrim Blyta,
Blerina Hoxha,
Shpend Haxhibeqiri,
Valdete Haxhibeqiri,
Emina Šabić Džananović,
Sabina Kučukalić,
Alma Bravo Mehmedbašić,
Abdulah Kučukalić,
Alma Džubur Kulenović,
Elma Ferić Bojić,
Damir Marjanović,
Nermina Kravić,
Esmina Avdibegović,
Mirnesa Muminović Umihanić,
Nenad Jakšić,
Ana Cima Franc,
Duško Rudan,
Miro Jakovljević,
Romana Babić,
Marko Pavlović,
Dragan Babić,
Branka Aukst Margetić,
Nada Božina,
Osman Sinanović,
Christiane Ziegler,
Bodo Warrings,
Katharina Domschke,
Jürgen Deckert,
Christiane Wolf,
Herzegovina
Publication year - 2019
Publication title -
psychiatria danubina
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.394
H-Index - 34
eISSN - 1849-0867
pISSN - 0353-5053
DOI - 10.24869/psyd.2019.256
Subject(s) - tph2 , psychopathology , single nucleotide polymorphism , psychology , allele , tryptophan hydroxylase , psychiatry , snp , serotonergic , clinical psychology , medicine , genetics , gene , biology , serotonin , genotype , receptor
Post-traumatic stress disorder (PTSD) is a stress related disorder which can occur in an individual after exposure to a traumatic event. It most commonly co-occurs with depression. The two disorders share not only overlapping symptoms, but also genetic diathesis. The aim of this study was to investigate the potential role of single nucleotide polymorphisms (SNPs) of the two serotonergic candidate genes 5-hydroxytryptamine receptor 1A (HTR1A) and tryptophan hydroxylase 2 (TPH2) in the pathogenesis of PTSD and comorbid psychopathology.