ROLE OF THE ALLELIC VARIATION IN THE 5-HYDROXYTRYPTAMINE RECEPTOR 1A (HTR1A) AND THE TRYPTOPHAN HYDROXYLASE 2 (TPH2) GENES IN THE DEVELOPMENT OF PTSD | Zendy

Aferdita Goci Uka | Zendy; Ferid Agani | Zendy; Afrim Blyta | Zendy; Blerina Hoxha | Zendy; Shpend Haxhibeqiri | Zendy; Valdete Haxhibeqiri | Zendy; Emina Sabic Dzananovic | Zendy; Sabina Kučukalić | Zendy; Alma Bravo Mehmedbasić | Zendy; Abdulah Kučukalić | Zendy; Alma Džubur Kulenović | Zendy; Elma Ferić Bojić | Zendy; Damir Marjanović | Zendy; Nermina Kravić | Zendy; Esmina Avdibegović | Zendy; Mirnesa Muminovic Umihanic | Zendy; Nenad Jakšić | Zendy; Ana Cima Franc | Zendy; Duško Rudan | Zendy; Miro Jakovljević | Zendy; Romana Babić | Zendy; Marko Pavlović | Zendy; Dragan Babić | Zendy; Branka Aukst Margetić | Zendy; Nada Božina | Zendy; Osman Sinanović | Zendy; Christiane Ziegler | Zendy; Bodo Warrings | Zendy; Katharina Domschke | Zendy; Jürgen Deckert | Zendy; Christiane Wolf | Zendy

Open Access

ROLE OF THE ALLELIC VARIATION IN THE 5-HYDROXYTRYPTAMINE RECEPTOR 1A (HTR1A) AND THE TRYPTOPHAN HYDROXYLASE 2 (TPH2) GENES IN THE DEVELOPMENT OF PTSD

Author(s) -

Aferdita Goci Uka,

Ferid Agani,

Afrim Blyta,

Blerina Hoxha,

Shpend Haxhibeqiri,

Valdete Haxhibeqiri,

Emina Sabic Dzananovic,

Sabina Kučukalić,

Alma Bravo Mehmedbasić,

Abdulah Kučukalić,

Alma Džubur Kulenović,

Elma Ferić Bojić,

Damir Marjanović,

Nermina Kravić,

Esmina Avdibegović,

Mirnesa Muminovic Umihanic,

Nenad Jakšić,

Ana Cima Franc,

Duško Rudan,

Miro Jakovljević,

Romana Babić,

Marko Pavlović,

Dragan Babić,

Branka Aukst Margetić,

Nada Božina,

Osman Sinanović,

Christiane Ziegler,

Bodo Warrings,

Katharina Domschke,

Jürgen Deckert,

Christiane Wolf

Publication year - 2019

Publication title -

psychiatria danubina

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.394

H-Index - 34

eISSN - 1849-0867

pISSN - 0353-5053

DOI - 10.24869/psyd.2019.256

Subject(s) - tph2 , tryptophan hydroxylase , allele , gene , receptor , tryptophan , genetics , psychology , serotonin , biology , amino acid , serotonergic

Post-traumatic stress disorder (PTSD) is a stress related disorder which can occur in an individual after exposure to a traumatic event. It most commonly co-occurs with depression. The two disorders share not only overlapping symptoms, but also genetic diathesis. The aim of this study was to investigate the potential role of single nucleotide polymorphisms (SNPs) of the two serotonergic candidate genes 5-hydroxytryptamine receptor 1A (HTR1A) and tryptophan hydroxylase 2 (TPH2) in the pathogenesis of PTSD and comorbid psychopathology.

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