Open AccessSTABILITY COMPARISON OF TULASI (Ocimum tenuiflorum L.) LEAF GEL HAND SANITIZER USING 0.5% AND 1% CMC-Na
Author(s) -
Dewa Ayu Made Adnya Swari,
Ni Putu Udayana A,
Ni Made Dharma Shantini S
Publication year - 2020
Publication title -
journal pharmaceutical science and application
Language(s) - English
Resource type - Journals
eISSN - 2301-7708
pISSN - 2301-7694
DOI - 10.24843/jpsa.2020.v02.i01.p04
Subject(s) - hand sanitizer , ocimum , moisturizer , chemistry , food science , chromatography , materials science , nuclear chemistry , medicine , traditional medicine
Background: Hand sanitizers contain 62% alcohol, softener and moisturizer. High alcohol content is able to irritate and make hands dry. A suitable moisturizer is needed for this preparation. Objective: The aim of this study is to evaluate the physical quality of gel hand sanitizer formulation of Ocimum tenuiflorum with CMC-Na as a gelling agent at a concentration of 0.5% and 1% CMC-Na. Methods: Data were collected at week-0,1,2,3,4, and replication is performed three times at each concentration of each measurement. The test results of the spread and adhesion data analysis using SPSS with a 95% confidence level. Results: Dispersive power and adhesion showed no significant difference (p <0.05) at week 0 and week 4 means second-hand sanitizer gel formulation concentration is not stable. Gel hand sanitizer leaves of Tulasi (Ocimum tenuiflorum) at a concentration of 1% CMC-Na stable from week 0 to week 3, while the concentration of 0.5% CMC-Na change at week 2. Gel hand sanitizer leaves of Tulasi (Ocimum tenuiflorum) with a gelling agent CMC-Na should need to be titrated. Conclusion: Gel hand sanitizer leaves of Tulasi (Ocimum tenuiflorum) that use concentrations of 1% CMC-Na as a gelling agent have a physical quality that is more stable than the organoleptic test concentration of 0.5% CMC-Na.
Keywords: Hand sanitizer, Ocimum tenuiflorum L., CMC-Na, Physical quality evaluation