Open AccessLAJU HIDROLISIS HEROIN DALAM AIR DAN PLASMA
Author(s) -
I Made Agus Gelgel Wirasuta,
M. A. Ningtyas,
Eka Indra Setyawan
Publication year - 2019
Publication title -
jurnal kimia (journal of chemistry)/jurnal kimia (jurusan kimia, fakultas matematika dan ilmu pengetahuan alam universitas udayana)
Language(s) - English
Resource type - Journals
eISSN - 2599-2740
pISSN - 1907-9850
DOI - 10.24843/jchem.2019.v13.i02.p11
Subject(s) - chromatography , chemistry , detection limit , codeine , hydrolysis , morphine , toluene , heroin , organic chemistry , pharmacology , drug , medicine
Heroine is hydrolyzed spontaneously in water and plasma. This will influence the determination, especially on the drug profiling. Spectrophotodensitometry has been used to analyze drug profiling of illicit heroine. This article reports the AL-TLC separation of heroine, 6-monoacetylmorphine (6-MAM), morphine, acetyl codeine, and the heroine hydrolysis in water and plasma. Heroin, 6-MAM, morphine, and acetyl codeine can be well-separated by mobile phase of toluene:siclohexane:diethyl amine (75:15:10, v/v). The limit of detection was 165.16 ng/spot and the limit of quantification was 550.55 ng/spot. Heroine was hydrolyzed in water and plasma under first order reaction. The rate of reaction was 0.55 min-1 in water with the half time reaction of 12.47 minutes. On the other hand the hydrolysis rate in plasma was slower with the half time of 16 minutes.
Keywords : hydrolysis, heroin, water, TLC-spectrophotodensitometer