Open AccessIN VIVO ANTI-INFLAMMATORY ACTIVITY OF DADAP LEAVES (Erythrina subumbrans (Hassk.) Merr)
Author(s) -
Ni Luh Kade Arman Anita Dewi,
Ni Luh Sintya,
Maria Malida Vernandes Sasadara,
Erna Cahyaningsih,
Putu Era Sandhi Kusuma Yuda,
Puguh Santoso
Publication year - 2021
Publication title -
international journal of biosciences and biotechnology/international journal of bioscience and biotechnology
Language(s) - English
Resource type - Journals
eISSN - 2655-9994
pISSN - 2303-3371
DOI - 10.24843/ijbb.2021.v09.i01.p03
Subject(s) - diclofenac sodium , in vivo , carrageenan , anti inflammatory , diclofenac , traditional medicine , chemistry , pharmacology , ethanol , inflammation , edema , biology , medicine , biochemistry , immunology , microbiology and biotechnology
Leguminosae is widely known for its anti-inflammatory properties due to the presence of several beneficial phytochemicals, including alkaloids, flavonoids, steroids, and saponins. Dadap (Erythrina subumbrans (Hassk.) Merr), a Leguminosae member, has empirically been used to treat inflammation. This research aimed to prove the anti-inflammatory effect of Dadap leaves scientifically. Dadap leaves were macerated in 96% ethanol to produced crude ethanol extract, followed by in vivo anti-inflammatory assay with the paw edema method. Three different doses of extract: 200, 300, and 400mg/kg BW, were administrated to Wistar rats to observed its ability in reducing carrageenan-induced inflammatory. All extract doses produced similar anti-inflammatory activity as compared to diclofenac sodium as a positive control. There is no significant difference among the three different doses. The results indicated that all treatment doses produced anti-inflammatory activity, but 200mg/kg BW administration was most efficient.