Open AccessGastric Histopathology of White Rats After Administration of Kedondong Leaves Extract
Author(s) -
I Wayan Sudira,
I Made Merdana,
Ketut Budiasa
Publication year - 2019
Publication title -
advances in tropical biodiversity and environmental sciences
Language(s) - English
Resource type - Journals
eISSN - 2622-0628
pISSN - 2549-6980
DOI - 10.24843/atbes.2018.v02.i01.p05
Subject(s) - histopathology , histology , h&e stain , necrosis , histopathological examination , stomach , oral administration , white pulp , staining , pathology , medicine , cellular infiltration , placebo , traditional medicine , biology , inflammation , lymphatic system , alternative medicine
This study aims to determine the effect of ethanol extract of Kedondong leaves (Spondias dulcis G. Forst) on the gastropathological histology of white rats (Mus musculus). A total of 25 healthy male white rats with weights 200-250 g were randomly divided into five groups. A control group was only given a placebo. The treatment group of kedondong leaf ethanol extract sequentially with a dose of 125, 250, 500 and 1,000 mg/kg/day for 21 days orally. On the 22nd day all of the animals were sacrificed for its the gastric, followed by processing for histopathological preparations with Hematoxylin Eosin (HE) staining. The results of the study in all treatment groups were found gastric histology changes in the form of mild inflammatory cell infiltration, mild fatty degeneration and mild necrosis. The number of mice that experienced histopathological changes differed in each group. It can be concluded that the oral administration of kedondong leaf ethanol extract with a range at a dose of 125-1000 mg/kg/d for 21 days does not cause significant histopathological structure disturbance in the stomach of male white rats.