Open AccessDecrease of Atherosclerosis Markers and Oxidative Stress After 1 Year Administration of Omega-3 Fatty Acids Supplements in Patients with Metabolic Syndrome
Author(s) -
Andreea Dragomir,
Emila Rusu,
Mihaela Posea,
Gabriela Radulian
Publication year - 2014
Publication title -
romanian journal of diabetes nutrition and metabolic diseases
Language(s) - English
Resource type - Journals
eISSN - 2284-6417
pISSN - 2068-8245
DOI - 10.2478/rjdnmd-2014-0022
Subject(s) - medicine , oxidative stress , adiponectin , metabolic syndrome , fish oil , endocrinology , leptin , polyunsaturated fatty acid , fatty acid , obesity , fish <actinopterygii> , biochemistry , insulin resistance , biology , fishery
Background and Aims: To assess the impact of 1 year administration of omega-3 fatty acids supplements on oxidative stress parameters and atherosclerosis progression. Material and Methods: A total of 284 patients with metabolic syndrome, aged 61±6.7 years, without clinical evidence of atherosclerosis were allocated to 2 groups, matched by sex and age: group A (140 patients) - diet according to ESC/EASD recommendations; group B (144 patients) - the same diet + capsules of fish oil (1g eicosapentanoic acid, 1g docosahexanoic acid, 0,1g a-tocopherol acetate). Body fat (BF) was measured by bioimpedance analysis. For oxidative stress evaluation we used the FormOx systems monitor on a blood drop and for progression of atherosclerosis the intima-media thickness (IMT) at common carotid artery. Patients were evaluated at baseline, after 6 months and 1 year. Results: IMT significantly decreased in group B vs group A at 1 year (p<0.0001) and was correlated with %BF (p<0.001), waist-to-hip ratio (WHR) (p=0.002), leptin (p< 0.001), adiponectin (p<0.05), leptin/adiponectin ratio (p< 0.001) and oxidative stress (p<0.001). Conclusions: One year administrations of omega-3 PUFA enriched diet reduces cardiovascular risk of metabolic syndrome patients, resulting in a significant decrease of oxidative stress and atherosclerosis progression