Open AccessMorphological Peculiarities of Parasitic (Trichosomoides crassicauda) Infection in Rat Urinary Bladder
Author(s) -
Vladyslav Sikora,
Mycola Lуndіn,
Nataliia Ivanivna Hyriavenko,
Roman Moskalenko,
Yulia Lуndіna,
Kateryna Sikora,
Ruslana Chyzhma,
Olena Diachenko,
Анатолий Николаевич Романюк
Publication year - 2021
Publication title -
macedonian veterinary review/macedonian veterinary review
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.178
H-Index - 6
eISSN - 1857-7415
pISSN - 1409-7621
DOI - 10.2478/macvetrev-2021-0019
Subject(s) - biology , pathology , parasite hosting , immune system , immunohistochemistry , staining , immunology , medicine , world wide web , computer science
Trichosomoides crassicauda ( T. crassicauda ) is a parasite commonly localized in the urinary bladder (UB) of laboratory and wild rats. The presence of these helminths can influence the prediction of pathological changes in the UB. Therefore, the purpose of this research was to make a comprehensive study of the features of the morphological changes in the UB wall of white laboratory rats as a result of T. crassicauda infestation. The study was performed on male rats using histological (Hematoxyline-Eosin and Alcian Blue staining) and immunohistochemical (Ki-67, Hsp70, Hsp90α, CD3 and CD20) methods. T. crassicauda was detected in both urine and UB samples. Morphological changes were observed as disruption in urothelial cell stratification and insignificant proliferative and immune responses in the UB. Increased heat shock protein levels were observed which may suggest a natural body’s resistance to this parasite.