Open AccessA New Biomarker in Acute-Decompensated Heart Failure. Preliminary Study
Author(s) -
Madalina Sorina Ababei,
A Câmpeanu,
D Nistorescu,
Ondin Zaharia,
Paul Portelli,
T Nanea
Publication year - 2019
Publication title -
medicina internă
Language(s) - English
Resource type - Journals
ISSN - 1220-5818
DOI - 10.2478/inmed-2019-0064
Subject(s) - medicine , acute decompensated heart failure , biomarker , heart failure , cardiology , gastroenterology , body weight , biochemistry , chemistry
Background. It is well known that the NT-proBNP in obese subjects is much lower than in normal weight subjects, making difficult to interpret it. In current practice the patients are frequently obese. In these conditions, a new biomarker, not influenced by weight, could be useful in acute-decompensated heart failure (ADHF). Aim. To determine CA-125 changes in obese and normal weight patients with ADHF. Method. The study group included 110 patients (mean age 72±10 years, 63% men) with ADHF caused by ischemic cardiomyopathy. The subjects were clinically, ecocardiographically and biologically (NT-proBNP, CA-125) evaluated. Results. The mean BMI was 27.6±5.8 kg/m 2 and 35 (33%) subjects were obese. CA-125 at admission was 53±33 U/mL and decreased at discharge to 34±17 U/mL, without any difference between males and females. There was a significant difference between NT-proBNP at admission in obese versus normoponderal patients (3207±1432 pg/mL versus 4457±2737 pg/mL (p=0.02)), which was maintained at discharge (1711±816 pg/mL versus 2674±1475 pg/mL (p=0.03)). In the same time, the CA-125 did not show statistically significant differences between obese and normoponderal subjects at admission (56±29 U/mL versus 51±20 U/mL (p=0.63)) and discharge (36±20 U/mL versus 33±16 U/mL (p=0.56)). Conclusions. CA-125 could be an useful biomarker in monitoring the obese patients with ADHF, better than NT-proBNP.