Open AccessInfluenza and sudden unexpected death: the possible role of peptide cross-reactivity
Author(s) -
Darja Kanduc
Publication year - 2018
Publication title -
infection international/infection international (electronic edition)
Language(s) - English
Resource type - Journals
eISSN - 2544-0349
pISSN - 2095-2244
DOI - 10.2478/ii-2018-0023
Subject(s) - titin , context (archaeology) , virology , cross reactivity , antigen , hemagglutinin (influenza) , cross reactions , virus , medicine , chemistry , immunology , biology , sarcomere , paleontology , myocyte
This study investigates the hypothesis that cross-reactions may occur between human cardiac proteins and influenza antigens, thus possibly representing the molecular mechanism underlying influenzaassociated sudden unexpected death (SUD). Using titin protein as a research model, data were obtained on (1) the occurrence of the titin octapeptide AELLVLLE or its mimic AELLVALE in influenza A virus hemagglutinin (HA) sequences; (2) the immunological potential of AELLVLLE and its mimic AELLVALE; (3) the possible role of the flanking amino acid aa) context of the two octapeptide determinants in eliciting cross-reactivity between the human cardiac titin protein and HA antigens.