Open AccessBerberis vulgaris alleviates Levodopa-induced dyskinesia in male mice
Author(s) -
Faezeh Mokarian,
Hamidreza Famitafreshi,
Mahsa Hadipour Jahromy
Publication year - 2018
Publication title -
herba polonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.169
H-Index - 4
eISSN - 2449-8343
pISSN - 0018-0599
DOI - 10.2478/hepo-2018-0023
Subject(s) - mptp , dyskinesia , dose , levodopa , parkinsonism , medicine , pharmacology , movement disorders , drug , parkinson's disease , anesthesia , disease
Summary Introduction: Parkinson’s disease is a chronic debilitating disease and many patients use Levodopa as a major treatment. However, this drug in long-term use causes a serious condition that is known as Levodopa-induced dyskinesia (LID). Berberis vulgaris (BV) has been known to be a good potential medication for neurologic diseases such as movement disorders. The aim of this study is to investigate the usefulness of BV for LID in mice. Material and methods: In this study, 48 adult male mice were randomly divided into six groups: 1) saline group, 2) MPTP + LID, 3) MPTP + LID + BV (5 mg/kg), 4) MPTP + LID + BV (10 mg/kg), 5) MPTP + LID + BV (20 mg/kg). MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) (30 mg/kg/day/ i.p. ) was used to induce Parkinson’s disease and Levodopa (50 mg/kg/day/ i.p. ) was used to induce LID. After induction of LID, mice received intraperitoneally ( i.p. ) different dosages of BV for 25 days. To investigate movement disorder improvement (dyskinesia), AIMS (Abnormal Involuntary Movement Scale) and cylinder tests were used. Results: Mice that received BV at dosages of 10 and 20 mg/kg/day showed improvement in AIMS and the cylinder test. Conclusion: BV is a useful drug for treating LID. So, parkinsonian disease patients may get a beneficial effect after treatment with BV for LID.