Open AccessRole of Mesenchymal Stem Cells—Derived Exosomes in Osteoarthritis Treatment
Author(s) -
Kristína Huňáková,
Marián Hluchý,
Mária Kuricová,
Karol Ševčík,
Ján Rosocha,
Valent Ledecký
Publication year - 2018
Publication title -
folia veterinaria
Language(s) - English
Resource type - Journals
eISSN - 2453-7837
pISSN - 0015-5748
DOI - 10.2478/fv-2018-0033
Subject(s) - microvesicles , mesenchymal stem cell , exosome , microbiology and biotechnology , osteoarthritis , regeneration (biology) , cartilage , microrna , stem cell , biology , immune system , chemistry , immunology , medicine , pathology , gene , biochemistry , anatomy , alternative medicine
Exosomes are nanovesicles that are involved in inter-cellular communication and are secreted by many types of cells. Exosomes secreted by stem cells can effectively transport bioactive proteins, messenger ribonucleic acids (mRNAs) and microribonucleic acids (miRNAs) organelles and play important roles in intercellular communication and the regulation of tissue regeneration. This transfer of bioactive molecules plays a main role in: tumor invasion and metastasis, immune and inflammation modulation, epithelial-mesenchymal transition and neurobiology. Mesenchymal Stem Cells (MSC) exosomes provide new perspectives for the development of an off-the-shelf and cell-free MSC therapy for the treatment of cartilage injuries and osteoarthritis. This report describes the progress in exosome studies and potential clinical use for osteoarthritis treatment.