Open AccessAssociation of X Chromosome Aberrations with Male Infertility
Author(s) -
Sh Xharra,
Emir Behluli,
A. Moder,
Hilada Nefić,
Rifat Hadžiselimović,
Gazmend Temaj
Publication year - 2021
Publication title -
acta medica bulgarica/acta medica bulgarica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.12
H-Index - 5
eISSN - 2719-5384
pISSN - 0324-1750
DOI - 10.2478/amb-2021-0051
Subject(s) - azoospermia , infertility , male infertility , chromosome , y chromosome , abnormality , genetics , klinefelter syndrome , x chromosome , azoospermia factor , andrology , biology , medicine , gene , pregnancy , psychiatry
Male infertility is caused by spermatogenetic failure, clinically noted as oligoor azoospermia. Approximately 20% of infertile patients carry a genetic defect. The most frequent genetic defect leading to azoospermia (or severe oligozoospermia) is Klinefelter syndrome (47, XXY), which is numerical chromosomal abnormality and Y- structural chromosome aberration. The human X chromosome is the most stable of all human chromosomes. The X chromosome is loaded with regions of acquired, rapidly evolving genes. The X chromosome may actually play an essential role in male infertility and sperm production. Here we will describe X chromosome aberrations, which are associated with male infertility.