Open AccessSchiff Bases and Triazolothiadiazines Derived from A Thiophene-Substituted 4-Amino-3-Mercapto-1,2,4-Triazole
Author(s) -
Gheorghe Roman
Publication year - 2019
Publication title -
acta chemica iaşi
Language(s) - English
Resource type - Journals
eISSN - 2067-2438
pISSN - 2067-2446
DOI - 10.2478/achi-2019-0011
Subject(s) - phenacyl , schiff base , chemistry , thiophene , 1,2,4 triazole , triazole , combinatorial chemistry , base (topology) , polymer chemistry , medicinal chemistry , organic chemistry , mathematics , mathematical analysis
4-Amino-5-(thiophen-2-ylmethyl)-2,4-dihydro-3 H -1,2,4-triazole-3-thione was synthesized and converted into the corresponding Schiff bases using several aromatic aldehydes. Reaction of this aminotriazolethione with phenacyl bromides lead to triazolothiadiazines, which were subsequently reduced with NaBH 4 to dihydrotriazolothiadiazines. The latter type of fused heterocycle has been also obtained directly by reacting one of the previously obtained Schiff base with phenacyl bromides. NMR analysis confirmed the structures of the synthesized compounds.